Presentations & Peer Reviewed Articles2019-06-30T21:18:55+00:00

Presentations and Peer Reviewed Articles

Presentations at Scientific Meetings

EASL International Liver Congress: Greg Everson, MD, and Brad Everson, HepQuant’s CEO and CBDO respectively, attended the EASL International Liver Congress, April 10-14, 2019  in Vienna, Austria.

Poster: A late breaker poster was released at EASL ILC 2019 discussing baseline and Day 85 HepQuant-SHUNT™ and Disease Severity Index (DSI) results from Intercept study 747-117 conducted in parallel to the Regenerate study. “Effect of Obeticholic Acid on Liver Function in Patients With Fibrosis due to NASH.” Naim Alkhouri (1), Gregory T. Everson (2), Steve Helmke (2), Jianfen Chen (3), Carl LaCerte (3), Michael Stenkilsson (3), Jeffrey E. Edwards (3). 1 Texas Liver Institute, University of Texas Health, San Antonio, TX; 2 HepQuant, Greenwood Village, CO; 3. Intercept Pharmaceuticals, Inc., San Diego, CA.

NASH-TAG Conference in Park City, Utah in January 2019

  • NASH-TAG 2019 (Poster 1): Title: Hepatobiliary and Metabolic Changes Occurring during Weight Loss and Subsequent Weight Maintenance in Obese Subjects: Implications for NASH Clinical Trials
  • NASH-TAG 2019 (Poster 2): Modeling the HepQuant STAT Test for Pre-screening NASH Subjects to Enrich Study Populations for the Desired Stage of Disease

AASLD Liver Meeting 2018: HepQuant attended the AASLD Liver Meeting in San Francisco, Nov. 9 – 13th. The company presented 2 posters:

  • Poster 1: “Defining and Monitoring Liver Disease in Chronic Hepatitis C:  A Comparison of the Disease Severity Index (DSI) from the HepQuant SHUNT test with Ishak Fibrosis (IFS) from Liver Biopsy.” Everson GT, Helmke SM.  Hepatology 2018;68:910A. Annotation: This study suggests that DSI may be more sensitive than IFS in measuring serial changes in disease in patients with chronic hepatitis C.
  • Poster 2: “Defining Disease Severity and Measuring Progression in Primary Sclerosing Cholangitis (PSC):  A Comparison of the Disease Severity Index (DSI) from the HepQuant SHUNT Test with Serum Alkaline Phosphatase (Alk Phos).”  Helmke SM, Everson GT. Hepatology 2018;1087A. Annotation: This study suggests that DSI may be more sensitive than Alk Phos in measuring serial changes in disease in patients with PSC.

NASH Summit 2018: “Identifying Potential Subjects for NASH Clinical Trials Using the HepQuant Quantitative Liver Tests” (Presentation) (Poster)

Discovery On Target (Boston, September 2018): “How HepQuant Tests May Aid Drug Development” (Presentation)

American Society of Clinical Oncology (ASCO) meeting (Jan. 19, 2018) highlighted a new potential use of HepQuant SHUNT – monitoring impact of cancer treatment on global liver function.

Poster: “Hepatic functional deterioration after locoregional therapy (LRT) for hepatocellular carcinoma (HCC) measured by hepatic cholate clearance: a pilot study”. Maarouf A Hoteit, MD (1); Christine Hsu, MD (1); Matthew H Levine, MD, PhD (2); Kimberly A. Forde ,MD (1); Kim Reiss, MD (3); Greg Nadolski, MD (4); Michael C. Soulen, MD (4); Laura E. Kron (1), Steve Helmke,PhD (5,6), Gregory T. Everson, MD (5,6); Edgar Ben-Josef, MD (7). 1 Division of Gastroenterology and Hepatology, 2 Division of Transplant Surgery, 3 Division of Hematology-Oncology, 4 Division of Interventional Radiology 7 Department of Radiation Oncology – all at the University of Pennsylvania, Philadelphia, PA. 5 Division of Gastroenterology and Hepatology, University of Colorado Denver, Aurora, CO. 6 Hepquant®, LLC, Denver, CO.

HepQuant was discussed at the October 2017 AASLD Meeting during an NAFLD Debrief

2017 AASLD: Diagnosing NASH and Assessing NASH Disease Severity with HepQuant-STAT, a Simple Quantitative Liver Function Test.” (Presentation)

Poster by Northwestern University Feinberg School of Medicine: “Evaluation of the Liver’s Function and Physiology Using HepQuant-SHUNT to Potentially Differentiate Irreversible from Reversible Hepatic Impairment in Patients with Chronic Passive Hepatic Congestion Secondary to Fontan Circulation”. Alexander A. Lemmer (1), Steve M. Helmke (2,3), Shannon Lauriski (2), Gregory T. Everson (2,3), Andrew Defreitas (4), Daniel R. Ganger (1). 1 Division of Gastroenterology and Hepatology, Northwestern University Feinberg School of Medicine, 2 Gastroenterology and Hepatology, University of Colorado, 3 HepQuant LLC, Denver, CO, 4 Cardiology, Ann & Robert H. Lurie Children’s Hospital of Chicago Disclosures: Everson and Helmke were formerly employed by the University of Colorado and are current employees of HepQuant LLC which is the exclusive licensee of intellectual property (IP) of University of Colorado, Everson, and Helmke. The IP encompasses 10 issued patents and several patents pending. Author Ganger receives a consultant fee from HepQuant LLC.

Presented at NASH Biomarker Conference in Wash DC May 2017
Principals of Kinetic Measures of Liver Function:   Focus on the HepQuant SHUNT Test (Presentation)

Presented at the AASLD Emerging Trends Conference on NAFLD in Washington DC in March 2017
Decreased Hepatic Reserve Determines the Risk of Varices in NASH Patients and in Chronic HCV Patients (Poster) (Abstract)

Presented at NASH-TAG in Park City Utah in January 2017

  • Diagnosing NASH Patients and Their Risk of Varices and Decompensation by a Global Measure of Liver Function, the HepQuant®-SHUNT Test (Poster) (Abstract)
  • A Disease Severity Index (DSI) from the HepQuant®-SHUNT Test is Reproducible and Quantifies Hepatic Impairment in Patients with Non-Alcoholic SteatoHepatitis (NASH), Chronic Hepatitis C (CHC), and Primary Sclerosing Cholangitis (PSC) (Poster) (Abstract)

Presented at the AASLD Liver Meeting in Boston in November 2016
Diagnosing NASH and Assessing NASH Disease Severity by a Global Measure of Liver Function, the HepQuant® (HQ)-SHUNT Test.  Steve M. Helmke, John D. Marr, Michael W. Cookson, Jennifer DeSanto, Shannon Lauriski, James F. Trotter, Gregory T. Everson. Hepatology 2016; 64:584A. (Poster) (Abstract)

(Presentation Archives)

Peer-Reviewed Articles

Below are peer-reviewed scientific articles, published in medical journals, that resulted from the QLFT Study of the HALT-C Trial and demonstrate the potential of research prototypes of HepQuant tests.

 Portal-systemic Shunting in Patients with Fibrosis or Cirrhosis due to Chronic Hepatitis C: the Minimal Model for Measuring Cholate Clearances and Shunt.  Alimentary Pharmacology & Therapeutics / 2007 The Authors, Aliment Pharmacol Ther 26, 401–410 /  Journal compilation / 2007 Blackwell Publishing Ltd.
 The Spectrum of Hepatic Functional Impairment in Compensated Chronic Hepatitis C: Results from the HALT-C Trial  Alimentary Pharmacology & Therapeutics / 2008 The Authors / Journal compilation 2008 / Blackwell Publishing Ltd.
  Quantitative Tests of Liver Function Measure Hepatic Improvement after Sustained Virologic Response: Results from the HALT-C Trial  Alimentary Pharmacology & Therapeutics / 2009 The Authors / Journal compilation 2009 / Blackwell Publishing Ltd.