April 2025
Assessment of the performance of a dual-sample oral cholate challenge test: The HepQuant DuO test
Michael P. McRae, Touraj Shokati, Uwe Christians, Steve M. Helmke, Gregory T. Everson | Clinica Chimica Acta | April 2025
Liver health is currently evaluated using nonspecific blood tests, fibrosis surrogates, and invasive procedures, none of which directly measure liver function and physiology. The validated HepQuant SHUNT test quantifies liver function and physiology and is linked to clinical outcomes. Herein we present the reliability of a simplified version, the dual-sample oral cholate challenge (HepQuant DuO) test. read more →
March 2025
Letter to the Editor: Enhancing the Diagnostic Performance of the Oral Cholate Challenge Test: Implications for Avoidance of Potentially Unnecessary Endoscopy
Tarek Hassanein, Andrew P. Keaveny, Parvez Mantry, Mitchell Shiffman, Michael Leise, Kamran Qureshi, Alastair D. Smith, Michael P. McRae, Joanne C. Imperial, Gregory T. Everson, the SHUNT-V Investigators | Alimentary Pharmacology & Therapeutics| March 2025
March 2025
Rencofilstat Treatment Improves Liver Function in MASH With Advanced Fibrosis as Quantified by HepQuant DuO
Stephen A. Harrison, Patrick Mayo, Todd Hobbs, Caroline Zhao, Carlos Canizares, Robert Foster, Michael P. McRae, Steve M. Helmke, Gregory T. Everson | Liver International | 01 March 2025
Coming Soon
Scientific Research: Posters & Presentations
Pilot Study of a Model Based on Noninvasive Assessments of Portal-Systemic Shunting (HepQuant DuO), Hepatic Fibrosis (FibroScan), and Splenic Congestion (Platelet Count) for Accurate Prediction of Portal Hypertension and Clinically Significant Portal Hypertension
Author: J.C. Imperial, M.P. McRae, and G.T. Everson
Event: Liver Connect | March 2025
Resmetirom Therapy of MASH-Associated Child Pugh A Cirrhosis Reduces Estimated Risk for Clinical Outcome Based on HepQuant RISK ACE Model
Author: J.C. Imperial, M.P. McRae, R. Taub, and G.T. Everson
Event: Liver Connect | March 2025
Quantifying Liver Function by Cholate Clearance in Extracorporeal Circuits with a Genetically Modified Porcine Liver and Brain-Dead Human Decedent
Author: A. Shaked, M.P. McRae, L. Lanieri, A. Sagar, K.C. Stiede, K.G. Swenson, P. Friend, G.T. Everson
Event: EASL May 2025
HepQuant DuO for Quantifying Liver Function and Physiology in the Clinic: Diagnostic Performance for Esophageal Varices in Patients with Treated and Active Chronic Hepatitis C
Author: M.L. Shiffman, T. Hassanein, J.C. Imperial, M.P. McRae and G.T. Everson for the HALT-C and SHUNT-V Investigators
Event: Global Hepatitis Summit | March 2025
The HepQuant DuO Test Finds Linkage Between Liver Blood Flow, Portal-Systemic Shunting, and Cardiac Hemodynamics in Fontan-Associated Liver Disease
Author: Y.Y. Kim, M.P. McRae, J. Rychik, G.T. Everson, M. Hoteit
Event: EASL May 2025
Coming Soon
Professional Organizations
Coming Soon
- American Association for the Study of Liver Disease (AASLD)
- American Gastroenterological Association (AGA)
- American College of Gastroenterology (ACG)
- American Society of Transplantation (AST)
- American Society of Pediatric Gastroenterology and Nutrition (NASPGHAN)
- European Association for the Study of the Liver (EASL)
- Asian Pacific Association for the Study of the Liver (APASL)
- International Liver Transplant Society (ILTS)
- American Heart Association (AHA)
- American Cancer Society (ACS)