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April 2025

Assessment of the performance of a dual-sample oral cholate challenge test: The HepQuant DuO test

Michael P. McRae, Touraj Shokati, Uwe Christians, Steve M. Helmke, Gregory T. Everson | Clinica Chimica Acta | April 2025

Liver health is currently evaluated using nonspecific blood tests, fibrosis surrogates, and invasive procedures, none of which directly measure liver function and physiology. The validated HepQuant SHUNT test quantifies liver function and physiology and is linked to clinical outcomes. Herein we present the reliability of a simplified version, the dual-sample oral cholate challenge (HepQuant DuO) test. read more →

HepQuant DuO

March 2025

Letter to the Editor: Enhancing the Diagnostic Performance of the Oral Cholate Challenge Test: Implications for Avoidance of Potentially Unnecessary Endoscopy

Tarek Hassanein, Andrew P. Keaveny, Parvez Mantry, Mitchell Shiffman, Michael Leise, Kamran Qureshi, Alastair D. Smith, Michael P. McRae, Joanne C. Imperial, Gregory T. Everson, the SHUNT-V Investigators | Alimentary Pharmacology & Therapeutics| March 2025

HepQuant DuO, HepQuant SHUNT

Alterations in Liver Perfusion in Adults with Fontan Circulation as Assessed by Dual Cholate Clearance

Yuli Y. Kim, Annique Nyman, Yuan-Shung Huang, Alexis Z. Tomlinson, Michael P. McRae, Greg T. Everson, Sumeet Vaikunth, Benjamin Rosenthal, Jack Rychik, Maarouf A. Hoteit | Journal of the American Heart Association | 2025 | March 2025

HepQuant SHUNT

March 2025

Rencofilstat Treatment Improves Liver Function in MASH With Advanced Fibrosis as Quantified by HepQuant DuO

Stephen A. Harrison, Patrick Mayo, Todd Hobbs, Caroline Zhao, Carlos Canizares, Robert Foster, Michael P. McRae, Steve M. Helmke, Gregory T. Everson | Liver International | 01 March 2025

HepQuant DuO, HepQuant SHUNT

November 2024

Measuring the Risk of Clinical Events (RISK ACE) by Quantifying Liver Function: A Patient-Centric Model

John Kittelson, Michael P. McRae, Gregory T. Everson | European Journal of Internal Medicine 2024; 132:160-163 | 29 November 2024

HepQuant DuO, HepQuant SHUNT

Scientific Research: Posters & Presentations

February 2023

Fourth Annual HCC-TAG Conference

Huntington Beach, CA

November 2022

Obesity & NASH Drug Development Summit

Boston, MA

November 2022

AASLD – The Liver Meeting 2022

Poster of Distinction: The Oral Cholate Challenge Test Defines Likelihood of Large Esophageal Varices in an Overweight and Obese US Population 

Maintenance Therapy with GLP-1 Receptor Agonists Does Not Impact the​ Clearance of Orally Administered Isotopes of Unconjugated Cholate

Cost-Effectiveness of the HepQuant DuO Test for the Management of Patients at Risk for Large Esophageal Varices

Poster of Distinction: Pilot Study of a Model Based on Noninvasive Assessments of Portal-Systemic Shunting (HepQuant DuO) 

Poster of Distinction: Resmetirom Therapy of MASH-Associated Child Pugh A Cirrhosis Reduces Estimated Risk for Clinical Outcome Based on HepQuant RISK ACE Model  

The Oral Cholate Challenge Test Identifies the MASH Patients with ≥F3 Fibrosis with Greatest Hepatic Impairment Who Show the Most Benefit from Short-term Rencofilstat Therapy

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