Publications

April 2025

Assessment of the performance of a dual-sample oral cholate challenge test: The HepQuant DuO test

Michael P. McRae, Touraj Shokati, Uwe Christians, Steve M. Helmke, Gregory T. Everson | Clinica Chimica Acta | April 2025

Liver health is currently evaluated using nonspecific blood tests, fibrosis surrogates, and invasive procedures, none of which directly measure liver function and physiology. The validated HepQuant SHUNT test quantifies liver function and physiology and is linked to clinical outcomes. Herein we present the reliability of a simplified version, the dual-sample oral cholate challenge (HepQuant DuO) test. read more →

March 2025

Letter to the Editor: Enhancing the Diagnostic Performance of the Oral Cholate Challenge Test: Implications for Avoidance of Potentially Unnecessary Endoscopy

Tarek Hassanein, Andrew P. Keaveny, Parvez Mantry, Mitchell Shiffman, Michael Leise, Kamran Qureshi, Alastair D. Smith, Michael P. McRae, Joanne C. Imperial, Gregory T. Everson, the SHUNT-V Investigators | Alimentary Pharmacology & Therapeutics| March 2025

March 2025

Rencofilstat Treatment Improves Liver Function in MASH With Advanced Fibrosis as Quantified by HepQuant DuO

Stephen A. Harrison, Patrick Mayo, Todd Hobbs, Caroline Zhao, Carlos Canizares, Robert Foster, Michael P. McRae, Steve M. Helmke, Gregory T. Everson | Liver International | 01 March 2025

November 2024

Measuring the Risk of Clinical Events (RISK ACE) by Quantifying Liver Function: A Patient-Centric Model

John Kittelson, Michael P. McRae, Gregory T. Everson | European Journal of Internal Medicine 2024; 132:160-163 | 29 November 2024

Advances in Noninvasive Measurement of Liver Function and Physiology: The HepQuant DuO Test

Michael P. McRae, John Kittelson, Steve M. Helmke, and Gregory T. Everson | Basic Clin Pharmacol Toxicol 2024 Jan 15. Mar;134(3):385-395

Alterations in Liver Perfusion in Adults with Fontan Circulation as Assessed by Dual Cholate Clearance

Yuli Y. Kim, Annique Nyman, Yuan-Shung Huang, Alexis Z. Tomlinson, Michael P. McRae, Greg T. Everson, Sumeet Vaikunth, Benjamin Rosenthal, Jack Rychik, Maarouf A. Hoteit | Journal of the American Heart Association | 2025 | March 2025

Cost-Effectiveness of an Oral Cholate Challenge Test for the Management of Patients at Risk for Large Esophageal Varices

Shailesh Chavan, Michael P. McRae, Kelly R. Pitts, Gregory T. Everson | Research Article | published 22 November 2024 PLOS ONE

Cholate Shunt, Oral Cholate Challenge and Endoscopic Lesions of Portal Hypertension: The SHUNT-V Study.

Mitchell Shiffman, K. Rajender Reddy, Michael, D. Leise3, Kamran Qureshi, Alastair D. Smith, Steve Helmke, John Kittelson, Michael P. McRae, Joanne C. Imperial, Gregory T. Everson, the SHUNT-V Investigators | Alimentary Pharmacology & Therapeutics, 2024; 61: 75-87

A Validated LC-MS/MS Assay for the Quantitation of Cholate Isotopes in Human Serum

Steve M. Helmke, Michael P. McRae, Uwe Christians, Touraj Shokati, Gregory T. Everson | The Journal of Applied Laboratory Medicine 2024 Aug 16

The Oral Cholate Challenge Test Quantifies Risk for Liver-Related Clinical Outcomes in Primary Sclerosing Cholangitis

Steve Helmke, John Kittelson, Joanne Imperial, Michael McRae, Gregory T. Everson | Gastro Hep Advances 2024