Publications

Liver Function and Portal-Systemic Shunting Quantified by the Oral Cholate Challenge Test and Risk for Large Esophageal Varices

Tarek Hassanein, Andrew P. Keaveny, Parvez Mantry, Alastair D. Smith, Michael P. McRae, John Kittelson, Steve Helmke, Gregory T. Everson for the SHUNT-V Investigators | Aliment Pharmacol Ther 2024 May 22

Hepatic Dysfunction Quantified by HepQuant DuO Outperforms Child-Pugh Classification in Predicting the Pharmacokinetics of Ampreloxetine

Jitendra Kanodia, Hugh Giovinazzo, Wayne Yates, David L. Bourdet, Steve M. Helmke, and Gregory T. Everson | Clin Pharmacol Ther 2024 Apr 23

Within Individual Reproducibility of a Dual Sample Oral Cholate Challenge Test (DuO) and Simplified Versions of the HepQuant SHUNT Test

Michael P. McRae, John Kittelson, Steve M. Helmke, and Gregory T. Everson | Clin Translational Sci 2024

Dynamic elevation of aromatic amino acids in Hepatitis C Virus induced cirrhosis after a standard meal

Hill KL, Haddad JA, Ali RO, Zhang GY, Quinn GM, Townsend E, Everson GT, Helmke SM, Bagheri M, Schoenfeld M, Yang S, Koh C, Levy EB, Kleiner DE, Sacks DB, Etzion O, Heller T. | Clinical and Translational Gastroenterology 2024;15:e00666

Advances in Noninvasive Measurement of Liver Function and Physiology: The HepQuant DuO Test

Michael P. McRae, John Kittelson, Steve M. Helmke, and Gregory T. Everson | Basic Clin Pharmacol Toxicol 2024 Jan 15. Mar;134(3):385-395

Portal-systemic shunting in patients with fibrosis or cirrhosis due to chronic hepatitis C: the minimal model for measuring cholate clearances and shunt

Everson GT, Martucci MA, Shiffman ML, Sterling RK, Morgan TR, Hoefs JC, The HALT-C Trial Group (2007) | Aliment Pharmacol Ther, 26(3):401-10

Compartmental model describing the physiological basis for the HepQuant SHUNT test

Michael P. McRae, Steve M. Helmke, James R. Burton Jr., and Gregory T. Everson | Transl Res. Volume 252, P53-63, February 2023

The within-individual reproducibility of the disease severity index from the HepQuant SHUNT test of liver function and physiology

Burton, James R. et al. | Transl Res. 2021 Jul;233:5-15

HepQuant SHUNT Detects Portal Hypertension in Early Stages of Clinically Compensated Chronic Liver Disease

Wieland A, Etzion O, Ali RO, Levy E, Kleiner D, Helmke SM, Heller T, Everson GT | Clin Gastroenterol Hepatol. 2021 Apr 22;S1542-3565(21)00464-X

Predicting clinical decompensation in patients with cirrhosis using the HepQuant SHUNT Test

Fallahzadeh MA, Hansen DJ, Trotter JF, Everson GT, Saracino G, Rahimi RS, Helmke S, Boutte J, Asrani SK | Aliment Pharmacol Ther. 2021 Apr;53(8):928-938